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IL12B antibody

CAT: 0710-FNab04219Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04219Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Synonyms
Interleukin-12 subunit beta (IL-12B) |Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) |IL-12 subunit p40|NK cell stimulatory factor chain 2 (NKSF2) |IL12B|NKSF2
Gene ID
3593
UniProt
P29460
Host
Rabbit
Reactivity
Human
Immunogen
Interleukin 12B
Target
IL12B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Cardiovascular, Developmental biology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
37 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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