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HSD17B11 antibody

CAT: 0710-FNab04023Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04023Size:100 µg
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Background
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Synonyms
Estradiol 17-beta-dehydrogenase 11|17-beta-hydroxysteroid dehydrogenase 11 (17-beta-HSD 11, 17bHSD11, 17betaHSD11) |17-beta-hydroxysteroid dehydrogenase XI (17-beta-HSD XI, 17betaHSDXI) |Cutaneous T-cell lymphoma-associated antigen HD-CL-03 (CTCL-associated antigen HD-CL-03) |Dehydrogenase/reductase SDR family member 8|Retinal short-chain dehydrogenase/reductase 2 (retSDR2) |Short chain dehydrogenase/reductase family 16C member 2|HSD17B11|DHRS8|PAN1B|SDR16C2
Gene ID
51170
UniProt
Q8NBQ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Hydroxysteroid (17-beta) dehydrogenase 11
Target
HSD17B11
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
28-300aa

UniProtKB · Q8NBQ5

Estradiol 17-beta-dehydrogenase 11

DHB11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NBQ5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSD17B11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.1.1.62
Processing
Precursor
Secondary accessions
Q96HF6, Q9UKU4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Endoplasmic reticulumLipid droplet

Biological process

Lipid biosynthesisLipid metabolismSteroid biosynthesis

Ligand

NADP

Molecular function

Oxidoreductase

Domain

Signal

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