HSD17B10 antibody

• Background:

  Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) .

• Synonyms:

  3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) |3-alpha- (17-beta) -hydroxysteroid dehydrogenase (NAD (+) ) |3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha (or 20beta) -hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2) |Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2

• Gene ID:

  3028

• UniProt:

  Q99714

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  Hydroxysteroid (17-beta) dehydrogenase 10

• Target:

  HSD17B10

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:1000-1:4000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  27 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  6C4

• Tested Applications:

  ELISA, WB

• Immunogen Sequence:

  1-261aa