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HSD17B10 antibody

CAT: 0710-FNab02824Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02824Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) .
Synonyms
3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) |3-alpha- (17-beta) -hydroxysteroid dehydrogenase (NAD (+) ) |3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha (or 20beta) -hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2) |Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2
Gene ID
3028
UniProt
Q99714
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Hydroxysteroid (17-beta) dehydrogenase 10
Target
HSD17B10
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:4000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
27 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6C4
Tested Applications
ELISA, WB
Immunogen Sequence
1-261aa

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