DNMT3A antibody

CAT: 0710-FNab02485Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02485Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Synonyms
DNA (cytosine-5) -methyltransferase 3A (Dnmt3a) |Cysteine methyltransferase DNMT3A|DNA methyltransferase HsaIIIA (DNA MTase HsaIIIA, M.HsaIIIA) |DNMT3A
Gene ID
1788
UniProt
Q9Y6K1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
DNA (cytosine-5-) -methyltransferase 3 alpha
Target
DNMT3A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

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