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GSDME antibody

CAT: 0710-FNab02348Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02348Size:100 µg
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Background
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms
Gasdermin-E|Inversely correlated with estrogen receptor expression 1 (ICERE-1) |Non-syndromic hearing impairment protein 5|Gasdermin-E, N-terminal (GSDME-NT) |Gasdermin-E, C-terminal (GSDME-CT) |GSDME|DFNA5|ICERE1
Gene ID
1687
UniProt
O60443
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Deafness, autosomal dominant 5
Target
GSDME
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-152aa

UniProtKB · O60443

Gasdermin-E

GSDME_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60443
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GSDME
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A4D156, B2RAX9, B3KT05, O14590, Q08AQ8, Q9UBV3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembrane

Disease

DeafnessNon-syndromic deafnessTumor suppressor

PTM

Isopeptide bondLipoproteinPalmitateUbl conjugation

Biological process

Necrosis

Domain

TransmembraneTransmembrane beta strand

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