CASP8 antibody

• Background:

  Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816) . It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro-and cleaved-caspase 8.

• Synonyms:

  Caspase-8 (CASP-8) |Apoptotic cysteine protease|Apoptotic protease Mch-5|CAP4|FADD-homologous ICE/ced-3-like protease|FADD-like ICE (FLICE) |ICE-like apoptotic protease 5|MORT1-associated ced-3 homolog (MACH) |Caspase-8 subunit p18|Caspase-8 subunit p10|CASP8|MCH5

• Gene ID:

  841

• UniProt:

  Q14790

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Caspase 8, apoptosis-related cysteine peptidase

• Target:

  CASP8

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, IHC, WB,IF,IP

• Field of Research:

  Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:100-1:400; IF: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-55 kDa, 25-32 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  2C2

• Tested Applications:

  ELISA, IHC, WB, IF, IP

• Immunogen Sequence:

  1-270aa