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CPTH2

CAT: 0804-HY-W013274-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W013274-02Size:10 mg
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Description
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) [1][2].
CAS Number
357649-93-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpth2.html
Purity
99.82
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
Molecular Formula
C14H14ClN3S
Molecular Weight
291.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.|[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4- (4'-chlorophenyl) thiazol-2-yl) hydrazone. J Med Chem. 2009 Jan 22;52 (2) :530-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GCN5/PCAF

Chemical Information

4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole

Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone is a member of the class of 1,3-thiazole bearing 2-cyclopentylidenehydrazino and 4-chlorophenyl substituents at positions 2 and 4 respectively. It has a role as an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a member of 1,3-thiazoles, a hydrazone and a member of monochlorobenzenes.

CAS Number357649-93-5
PubChem CID25193530
IUPAC Name4-(4-chlorophenyl)-N-(cyclopentylideneamino)-1,3-thiazol-2-amine
Molecular FormulaC14H14ClN3S
Molecular Weight291.8
XLogP4.2
Topological Polar Surface Area65.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity321
SMILES
C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1
InChI
InChI=1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)
InChIKey
YYTHPXHGWSAKIZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)-1,3-thiazole
CAS: 357649-93-5
CID: 25193530
Formula: C14H14ClN3S
MW: 291.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight291.8
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass291.0596963
Monoisotopic Mass291.0596963
Topological Polar Surface Area65.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity321
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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