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DBCO-PEG8-VKG-CPT2

CAT: 0804-HY-175272Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175272Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DBCO-PEG8-VKG-CPT2 is a drug-linker conjugate for ADC. DBCO-PEG8-VKG-CPT2 consists of a topoisomerase 1 inhibitor (7-MAD-MDCPT) and a stable and cleavable linker (DBCO-PEG8-VKG) (HY-175426). DBCO-PEG8-VKG-CPT2 can be used for synthesis of ADCs[1].
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(C)C)C(N[C@H](C(NCC(NCC(C1=CC2=C(C=C1N=C3C4=CC([C@]5(CC)O)=C6COC5=O)OCO2)=C3CN4C6=O)=O)=O)CCCCN)=O)=O)CCC(N7C8=C(C#CC9=C(C7)C=CC=C9)C=CC=C8)=O
Molecular Formula
C73H93N9O20
Molecular Weight
1416.57
References & Citations
[1]High PC, et al. Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models. bioRxiv [Preprint]. 2025 Jun 24:2025.06.18.660406.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I

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