Ac-VAD-AFC

• Description:

  Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases[1][2].

• UNSPSC:

  12352209

• Target:

  Caspase

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ac-vad-afc.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC2=C(C=C1C(F)(F)F)C=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)C(C)C)=O)C)=O)CC(O)=O)=O)=C2

• Molecular Formula:

  C24H27F3N4O8

• Molecular Weight:

  556.49

• References & Citations:

  [1]Choi WS, et al. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. J Neurochem. 2001;77 (6) :1531-1541.|[2]Posadas I, et al. Acetaminophen induces human neuroblastoma cell death through NFKB activation. PLoS One. 2012;7 (11) :e50160.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported