Sucrosofate (potassium)

Sucrosofate (potassium)

• CAS Number: 73264-44-5
• UNSPSC Description: Sucrosofate (Sucrose octasulfate) potassium is a sucrose acid that can be used to prepare liposomes to deliver Irinotecan (HY-16562). Irinotecan is an inhibitor of topoisomerase Topo I and is commonly used in colon and rectal cancer research. Sucrosofate nanoliposome preparation loaded with Irinotecan, also known as PEP02 or MM-398[1][2].
• Target Antigen: Biochemical Assay Reagents
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/sucrosofate-potassium.html
• Solubility: H2O : 175 mg/mL (ultrasonic)
• Smiles: O=S(OC[C@@]1([C@H]([C@@H]([C@H](O1)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)(O[K])=O
• Molecular Weight: 1287.52
• References & Citations: [1]Ko A H, Tempero M A, Shan Y S, et al. A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer[J]. British journal of cancer, 2013, 109(4): 920-925.|[2]Klinz S G, Zheng J, De Souza R, et al. Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F] FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model[J]. Molecular Cancer Therapeutics, 2013, 12(11_Supplement): C293-C293.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported