Products for Research Use Only
RegisterLogin

Pioglitazone (potassium)

CAT: 0804-HY-13956BSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13956BSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium can be used in diabetes research[2][3][4].
CAS Number
1266523-09-4
Product Name Alternative
U 72107 (potassium)
UNSPSC
12352005
Target
Ferroptosis; PPAR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pioglitazone-potassium.html
Solubility
10 mM in DMSO
Smiles
CCC1=CC=C(N=C1)CCOC2=CC=C(C=C2)CC(SC([N-]3)=O)C3=O.[K+]
Molecular Formula
C19H19KN2O3S
Molecular Weight
394.53
References & Citations
[1]Kenji Kuwabara, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist,2-methyl-c-5-[4-[5-methyl-2- (4-methylphenyl) -4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. J Pharmacol Exp Ther. 2004 Jun;309 (3) :970-7.|[2]A Puddu, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177 (1-3) :79-84.|[3]Naoto Kubota, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281 (13) :8748-55.|[4]Rania A Elrashidy, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17 (3) :324-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PPARα; PPARβ/δ; PPARγ

Related Products

CatalogName
HY-13956-01Pioglitazone
HY-14601-01Pioglitazone (hydrochloride)
HY-13956C(R) -Pioglitazone
HY-13956R-01Pioglitazone (Standard)
HY-13956SPioglitazone-d4
HY-W738533Pioglitazone-d4 (hydrochloride)
HY-13956S1Pioglitazone-d4 (alkyl)
HY-13956A(R) -Pioglitazone-d1
HY-14601R-01Pioglitazone (hydrochloride) (Standard)
HY-144145S-01Hydroxy Pioglitazone (M-II) -d4

Alternative Products

CatalogName
MBS5804532Pioglitazone potassium
B2117-25Pioglitazone

Popular Products