Sucrosofate (potassium) (Standard)

• Description:

  Sucrosofate (potassium) (Standard) is the analytical standard of Sucrosofate (potassium) . This product is intended for research and analytical applications. Sucrosofate (Sucrose octasulfate) potassium is a sucrose acid that can be used to prepare liposomes to deliver Irinotecan (HY-16562) . Irinotecan is an inhibitor of topoisomerase Topo I and is commonly used in colon and rectal cancer research. Sucrosofate nanoliposome preparation loaded with Irinotecan, also known as PEP02 or MM-398[1][2].

• Product Name Alternative:

  Sucrose octasulfate (potassium) (Standard)

• UNSPSC:

  12352005

• Target:

  Biochemical Assay Reagents; Reference Standards

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sucrosofate-potassium-standard.html

• Smiles:

  O=S (OC[C@@]1 ([C@H] ([C@@H] ([C@H] (O1) COS (=O) (O[K]) =O) OS (=O) (O[K]) =O) OS (=O) (O[K]) =O) O[C@@H]2[C@@H] ([C@H] ([C@@H] ([C@H] (O2) COS (=O) (O[K]) =O) OS (=O) (O[K]) =O) OS (=O) (O[K]) =O) OS (=O) (O[K]) =O) (O[K]) =O

• Molecular Formula:

  C12H14K8O35S8

• Molecular Weight:

  1287.52

• References & Citations:

  [1]Ko A H, Tempero M A, Shan Y S, et al. A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer[J]. British journal of cancer, 2013, 109 (4) : 920-925.|[2]Klinz S G, Zheng J, De Souza R, et al. Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F] FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model[J]. Molecular Cancer Therapeutics, 2013, 12 (11_Supplement) : C293-C293.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  73264-44-5