Potassium oxonate

Potassium oxonate

• CAS Number: 2207-75-2
• UNSPSC Description: Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/Oxonic-acid-potassium-salt.html
• Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(O[K])C1=NC(O)=NC(O)=N1
• Molecular Weight: 195.17
• References & Citations: [1]Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9.|[2]Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8.|[3]Yoshisue K, et al. Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats. Drug Metab Dispos. 2000 Oct;28(10):1162-7.|[4]Chen Y, et al. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Biomed Pharmacother. 2019 Oct;118:109195.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported