GNE-495

• UNSPSC Description:

  GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.

• Target Antigen:

  MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GNE-495.html

• Purity:

  99.40

• Solubility:

  DMSO : 2.17 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4

• Molecular Weight:

  405.42

• References & Citations:

  [1]Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1449277-10-4