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OR-1896

CAT: 0804-HY-135746-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135746-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation[1].
CAS Number
220246-81-1
UNSPSC
12352005
Target
Apoptosis; Drug Metabolite; Phosphodiesterase (PDE) ; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/or-1896.html
Purity
99.04
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC(NC1=CC=C(C([C@H](C)C2)=NNC2=O)C=C1)=O
Molecular Formula
C13H15N3O2
Molecular Weight
245.28
References & Citations
[1]Papp, Z, et al., Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159 (2) :82-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE3

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