Products for Research Use Only
RegisterLogin

S 18986

CAT: 0804-HY-10936-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10936-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2].
CAS Number
175340-20-2
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-18986.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S1(C2=CC=CC=C2N3[C@@](CCC3)([H])N1)=O
Molecular Formula
C10H12N2O2S
Molecular Weight
224.28
References & Citations
[1]Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16 (5) :e193-212.|[2]Bourasset F, et al. Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [ (S) -2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab Dispos. 2005 Aug;33 (8) :1137-43.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AMPA Receptor

Related Products

CatalogName
HY-125845B(S, S, S) -AHPC
HY-120217A(S, S, S) -VH032
HY-172298(R, S, S, S) -Orlistat
HY-112078B(S, S, S) -AHPC-Me
HY-123109A-01(S, S, S) -AHPC-Boc
HY-125845A-01(S, S, S) -AHPC (hydrochloride)
HY-78931B-01(S, S, S, S, R) -Boc-Dap-NE
HY-130671B(S, S) -DPPG
HY-122715(S, S) -D211
HY-137428-01(S, S) -EDDS

Alternative Products

CatalogName
B5493-10S 18986
461016R-18986
TL501704Pou2f1 Mouse shRNA Plasmid (Locus ID 18986)
SR420199Pou2f1 Mouse siRNA Oligo Duplex (Locus ID 18986)
TL501704VPou2f1 Mouse shRNA Lentiviral Particle (Locus ID 18986)

Popular Products