LTB4-IN-1

• Description:

  LTB4-IN-1 (Compound 6) is a leukotriene synthesis (LTB4) inhibitor with an IC50 of 70 nM[1].

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Cycloheptaneacetamide,_N-_methylsulfonyl_-_alpha_-[4-_2-quinolinylmethoxy_phenyl]-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NS(=O)(C)=O)C(C1=CC=C(OCC2=NC3=CC=CC=C3C=C2)C=C1)C4CCCCCC4

• Molecular Formula:

  C26H30N2O4S

• Molecular Weight:

  466.59

• References & Citations:

  [1]Hatzelmann A, et al. Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY X1005 and other quinoline derivatives in intact cells and a cell-free system--implications for the function of 5-lipoxygenase activating protein. Biochem Pharmacol. 1994 Jun 15;47 (12) :2259-68.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LTB4

• CAS Number:

  [133012-00-7]