LTB4-IN-2

• Description:

  LTB4-IN-2 (Comopund 6x) is a Leukotriene B4 (LTB4) inhibitor. LTB4-IN-2 inhibits Leukotriene B4 formation (IC50: 1.15 μM) by selectively targeting 5-Lipoxygenase-activating protein (FLAP) . LTB4-IN-2 can be used for anti-inflammatory research[1].

• UNSPSC:

  12352005

• Target:

  FLAP; Leukotriene Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ltb4-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CCC1=CC(C2=NN=C(SCC3=NC4=C(C=CC=C4)S3)N2C5=CC=CC=C5)=CC=C1

• Molecular Formula:

  C24H17N5S2

• Molecular Weight:

  439.56

• References & Citations:

  [1]Olğaç A, et al. Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein. ACS Omega. 2023 Aug 18;8 (34) :31293-31304.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported