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12-epi-LTB4

CAT: 0804-HY-137350-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-137350-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12-epi-LTB4 is an agonist for BLT1 and BLT2. 12-epi LTB4 exhibits a partial agonistic activity against mBLT1 and mBLT2, and induces phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes[1][2].
CAS Number
83709-73-3
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-epi-ltb4.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](CCCC(O)=O)/C=C\C=C\C=C\[C@@H](O)C/C=C\CCCCC
Molecular Formula
C20H32O4
Molecular Weight
336.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yokomizo T, et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276 (15) :12454-9.|[2]Iizuka Y, et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005 Jul 1;280 (26) :24816-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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