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ISAM-CG557

CAT: 0804-HY-175666Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175666Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ISAM-CG557 is a selective CB2R agonist, with a Ki of 54.6 nM. ISAM-CG557 reduces intracellular ROS levels and caspase activity. ISAM-CG557 exhibits significant MAPK bias and moderate G-protein bias, with CB2R EC50s of 0.60 nM (cAMP), 60.9 nM (β-arrestin) and 0.03 nM (MAPK) . ISAM-CG557 exerts potent anti-inflammatory effects by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines in cells. ISAM-CG557 can be used for the study of neuroinflammatory and neurodegenerative disorders[1].
UNSPSC
12352100
Target
Arrestin; Cannabinoid Receptor; Caspase; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C([C@H]1N(C(C2=NN(CC3=CC=C(F)C=C3)C4=C2C=CC=C4)=O)CCCC1)N
Molecular Formula
C21H21FN4O2
Molecular Weight
380.42
References & Citations
[1]Gioé-Gallo C, et al. Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB2 Agonists with Neuroprotective Effects. J Med Chem. 2025 Aug 28;68 (16) :17103-17129.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2

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