ISAM-140

• Description:

  ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Adenosine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/isam-140.html

• Purity:

  99.85

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(C)N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)OC(C)C

• Molecular Formula:

  C19H19N3O3

• Molecular Weight:

  337.37

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]El Maatougui A, et al. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59 (5) :1967-83.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Adenosine A2B receptor (A2BR)

• CAS Number:

  932191-62-3