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Men 10376

CAT: 804-HY-P1276Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
CAS Number
[135306-85-3]
Product Name Alternative
Neurokinin-2 receptor antagonist
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Men_10376.html
Solubility
10 mM in H2O
Smiles
NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](NC([C@H](C(C)C)NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CNC5=C4C=CC=C5)=O)=O)CC6=CNC7=C6C=CC=C7)=O)=O
Molecular Formula
C57H68N12O10
Molecular Weight
1081.22
References & Citations
[1]Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51 (25) :1929-36.|[2]Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257 (3) :1172-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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