MEN 10207 (acetate)

CAT: 0804-HY-151413ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151413ASize:1 Each
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Description
MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10) -induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10) -induced enhancement of bronchoconstriction in anesthetized guinea pigs[1].
UNSPSC
12352209
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
N=C(NCCC[C@H](NC([C@H](NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](CC3=CNC4=CC=CC=C34)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)C(C)C)=O)=O)CC6=CNC7=CC=CC=C67)=O)C(N)=O)N.CC(O)=O.[x]
Molecular Formula
C57H68N14O10.xC2H4O2
Molecular Weight
1109.24
References & Citations
[1]Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257 (3) :1172-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK2R

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