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(Arg) 9

CAT: 0804-HY-P0133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P0133Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Arg) 9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg) 9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].
CAS Number
143413-47-2
Product Name Alternative
Nona-L-arginine; Peptide R9
UNSPSC
12352209
Target
Ser/Thr Protease
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_Arg_9.html
Solubility
H2O
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C54H110N36O10
Molecular Weight
1423.69
References & Citations
[1]Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34 (2) :173-81.|[2]Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35 (6) :993-1004.|[3]Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275 (47) :36741-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2

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