c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]

• UNSPSC Description:

  c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].

• Target Antigen:

  Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/c-arg-arg-arg-arg-dip-dip-dip.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H](C(N[C@@H](C(N[C@@H](C1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C2=CC=CC=C2)C3=CC=CC=C3)[C@@H](NC([C@@H](NC([C@H](NC([C@H](N1)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C4=CC=CC=C4)C5=CC=CC=C5)=O)C(C6=CC=CC=C6)C7=CC=CC=C7

• Molecular Weight:

  1294.55

• References & Citations:

  [1]Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2619853-87-9