RG-12915

• Description :

  RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM.

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/RG-12915.html

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C2O[C@](CCCC3)([H])[C@]3([H])C2=CC(Cl)=C1)N[C@@H]4CN5CCC4CC5

• Molecular Formula :

  C20H25ClN2O2

• Molecular Weight :

  360.88

• References & Citations :

  [1]Fitzpatrick LR, et al. RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. J Pharmacol Exp Ther. 1990 Aug;254 (2) :450-5.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  Lactoferrin

• CAS Number :

  [136174-04-4]