Physalin O

CAT: 0804-HY-N10023-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N10023-01Size:1 mg
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Description
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities[1][2].
CAS Number
[120849-18-5]
UNSPSC
12352005
Target
NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/physalin-o.html
Purity
99.35
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]34[C@](C([C@](O3)([C@@]5([H])[C@]([C@@]6(C(CC=CC6=O)=C[C@H]5O)C)([H])CC[C@@]4(C(O2)=O)O)O)=O)([H])[C@@]7(C[C@H]1OC([C@H]7C)=O)C
Molecular Formula
C28H32O10
Molecular Weight
528.55
References & Citations
[1]Kuo PC, et al. Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. Org Lett. 2006 Jul 6;8 (14) :2953-6.|[2]Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77 (5) :441-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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