Physalin O

• Description:

  Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities[1][2].

• UNSPSC:

  12352005

• Target:

  NO Synthase

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/physalin-o.html

• Purity:

  99.35

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@]34[C@] (C ([C@] (O3) ([C@@]5 ([H]) [C@] ([C@@]6 (C (CC=CC6=O) =C[C@H]5O) C) ([H]) CC[C@@]4 (C (O2) =O) O) O) =O) ([H]) [C@@]7 (C[C@H]1OC ([C@H]7C) =O) C

• Molecular Formula:

  C28H32O10

• Molecular Weight:

  528.55

• References & Citations:

  [1]Kuo PC, et al. Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. Org Lett. 2006 Jul 6;8 (14) :2953-6.|[2]Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77 (5) :441-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  120849-18-5