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Physalin B

CAT: 0804-HY-N7695Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7695Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].
CAS Number
23133-56-4
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/physalin-b.html
Purity
96.98
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@H](OC1=O)C2)(OC3=O)[C@](O[C@@]45C6=O)([C@@]3(CC[C@@]7([H])[C@@]4([H])CC=C(CC=C8)[C@@]7(C8=O)C)O)[C@]6([H])[C@]2([C@@]1([H])CO5)C
Molecular Formula
C28H30O9
Molecular Weight
510.53
References & Citations
[1]Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341.|[2]Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36 (4) :517-527.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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