Physalin A

• UNSPSC Description:

  Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc[1][2][3][4].

• Target Antigen:

  Akt; Apoptosis; Autophagy; JAK; mTOR; NF-κB; p38 MAPK; PI3K; STAT

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Autophagy;Epigenetics;JAK/STAT Signaling;MAPK/ERK Pathway;NF-κB;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/physalin-a.html

• Purity:

  99.22

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]([C@@](OC1=O)([H])C2)(OC3=O)[C@@]([C@@]3(CC[C@@]([C@]45C)([H])[C@@]6([H])[C@@H](C=C4CC=CC5=O)O)O)(O[C@@]76O)[C@](C7=O)([H])[C@]2(C1=C)C

• Molecular Weight:

  526.53

• References & Citations:

  [1]Shin JM, et al. Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes. BMC Complement Altern Med. 2019 May 9;19(1):101.|[2]Kang N, et al. Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway. Mol Cell Biochem. 2016 Apr;415(1-2):145-55.|[3]Lu R, et al. Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects. J Orthop Translat. 2023 Jan 25;39:74-87.|[4]Zhu F, et al. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling. Oncotarget. 2016 Feb 23;7(8):9462-76.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  23027-91-0