Physalin H

• Description:

  Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; Hedgehog

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/physalin-h.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@] ([C@H] (OC1=O) C2) (OC3=O) [C@] (O[C@@]45C6=O) ([C@]3 (CC[C@@] ([C@] ([C@@]7 (CC=C8) Cl) (C8=O) C) ([H]) [C@@]4 ([H]) C[C@H]7O) O) [C@@]6 ([H]) [C@]2 ([C@@]1 ([H]) CO5) C

• Molecular Formula:

  C28H31ClO10

• Molecular Weight:

  562.99

• References & Citations:

  [1]Arai MA, eta l. Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem. 2014 Jan 13;10:134-40.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  70241-09-7