MC-DOXHZN

• Description :

  MC-DOXHZN ((E/Z) -Aldoxorubicin) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties[1].

• Product Name Alternative :

  (E/Z) -Aldoxorubicin; Doxorubicin (6-maleimidocaproyl) hydrazone

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Drug-Linker Conjugates for ADC; Topoisomerase

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/DOXO-EMCH.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1

• Molecular Formula :

  C37H42N4O13

• Molecular Weight :

  750.75

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Daunorubicins/Doxorubicins; Topo II

• CAS Number :

  [151038-96-9]