MC-DOXHZN

• Description:

  MC-DOXHZN ((E/Z) -Aldoxorubicin) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties[1].

• Product Name Alternative:

  (E/Z) -Aldoxorubicin; Doxorubicin (6-maleimidocaproyl) hydrazone

• UNSPSC:

  12352203

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Drug-Linker Conjugates for ADC; Topoisomerase

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/DOXO-EMCH.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]1 (O[C@H]2C[C@@] (/C (CO) =N\NC (CCCCCN3C (C=CC3=O) =O) =O) (O) CC (C2=C4O) =C (O) C5=C4C (C6=C (OC) C=CC=C6C5=O) =O) O[C@@H] (C) [C@@H] (O) [C@@H] (N) C1

• Molecular Formula:

  C37H42N4O13

• Molecular Weight:

  750.75

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Daunorubicins/Doxorubicins; Topo II

• CAS Number:

  151038-96-9