PSI-7409

• UNSPSC Description:

  PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.

• Target Antigen:

  HCV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PSI-7409.html

• Purity:

  98.03

• Solubility:

  DMF : < 1 mg/mL (ultrasonic;warming;heat to 80°C)|DMSO : < 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O

• Molecular Weight:

  500.16

• References & Citations:

  [1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2022 Dec 8;641:50-56.|Cell. 2022 Nov 10;185(23):4347-4360.e17.|J Virol Methods. 2021 Sep 14;298:114283.|Microbiol Spectr. 2022 Aug 18;e0272922.|Asian J Pharm Sci. 21 October 2021.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1015073-42-3