PSI-7409

• Description :

  PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977) . Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  HCV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PSI-7409.html

• Purity :

  98.03

• Solubility :

  DMF : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O

• Molecular Formula :

  C10H16FN2O14P3

• Molecular Weight :

  500.16

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54 (8) :3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2023 Jan 22:641:50-56.|Cell. 2022 Nov 10;185 (23) :4347-4360.e17.|J Virol Methods. 2021 Dec:298:114283.|Microbiol Spectr. 2022 Oct 26;10 (5) :e0272922.|Asian J Pharm Sci. 2021 Nov;16 (6) :772-783.|J Med Chem. 2025 Jun 26;68 (12) :12414-12433.

• CAS Number :

  [1015073-42-3]