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PSI-7409

CAT: 0804-HY-15745Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15745Size:1 Each
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Description
PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977) . Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.
CAS Number
[1015073-42-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PSI-7409.html
Purity
98.03
Solubility
DMF : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O[C@@H]([C@@](C)(F)[C@H](N1C(NC(C=C1)=O)=O)O2)[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O
Molecular Formula
C10H16FN2O14P3
Molecular Weight
500.16
Precautions
H315, H319, H335
References & Citations
[1]Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54 (8) :3187-96.|[2]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Antiviral Res. 2020 Mar;175:104708.|Biochem Biophys Res Commun. 2023 Jan 22:641:50-56.|Cell. 2022 Nov 10;185 (23) :4347-4360.e17.|J Virol Methods. 2021 Dec:298:114283.|Microbiol Spectr. 2022 Oct 26;10 (5) :e0272922.|Asian J Pharm Sci. 2021 Nov;16 (6) :772-783.|J Med Chem. 2025 Jun 26;68 (12) :12414-12433.

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