PSI-697

• Description:

  PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

• Product Name Alternative:

  P-Selectin Inhibitor

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  P-selectin

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PSI-697.html

• Purity:

  99.79

• Solubility:

  DMSO : ≥ 45.8 mg/mL

• Smiles:

  O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O

• Molecular Formula:

  C21H18ClNO3

• Molecular Weight:

  367.83

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2- (4-chlorobenzyl) -3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.|[2]Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97 (3) :400-7.|[3]Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44 (3) :625-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  851546-61-7