RegisterLogin

LY 303511

CAT: 0804-HY-15643Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15643Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
CAS Number
[154447-38-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY-303511.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(N2CCNCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
Molecular Formula
C19H18N2O2
Molecular Weight
306.36
Precautions
P264-P270-P330-P501
References & Citations
[1]Bodenstine TM, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. Cancer Res. 2010 Dec 1;70 (23) :10002-11.|[2]Shenoy K, et al. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 2009 Mar 1;69 (5) :1941-50.|[3]El-Kholy W, Macdonald PE, Lin JH, The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K (V) currents via a direct mechanism. FASEB J. 2003 Apr;17 (6) :720-2.|[4]Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR) - and non-mTOR-dependent mechanisms. J Pharmacol Exp Ther. 2005 Sep;314 (3) :1134-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Int J Mol Sci. 2023 Jul 28;24 (15) :12079.|bioRxiv. 2025 Nov 8.|Cancer Cell Int. 2021 Jun 5;21 (1) :291.|Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2405534121.

Related Products

CatalogName
HY-108963LY 170198
HY-119211LY 97241
HY-120298LY-510929
HY-P1618LY-281217
HY-111197LY-2300559
HY-120020LY-395153
HY-129807LY-228729
HY-136844LY-300168
HY-156807LY 367265
HY-117799LY-426965

Alternative Products

CatalogName
sc-202215ALY 303511
bs-6665C-01LY-303511
A15147-10LY 303511 10mg
T4423-01LY 303511 hydrochloride
MBS130242-01LY-303511-hydrochloride
A15147-100LY 303511 100mg
A15147-5LY 303511 5mg
A15147-25LY 303511 25mg
A15147-50LY 303511 50mg
A15147-10mM-DLY 303511 10mM * 1mL in DMSO

Popular Products