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INCB 3284 (dimesylate)

CAT: 0804-HY-15450Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15450Size:1 Each
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Description
INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.
CAS Number
887401-93-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/incb-3284-dimesylate.html
Purity
98.0
Solubility
DMSO : ≥ 83.3 mg/mL
Smiles
O=C(NCC(N[C@H]1CN([C@H]2CC[C@](C3=CC=C(OC)N=C3)(O)CC2)CC1)=O)C4=CC=CC(C(F)(F)F)=C4.CS(=O)(O)=O.CS(=O)(O)=O
Molecular Formula
C28H39F3N4O10S2
Molecular Weight
712.76
Precautions
H302, H315, H319, H335
References & Citations
[1]Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2 (6) :450-4.|[2]McMillin M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2

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