INCB-057643

• Description :

  INCB-057643 is a novel, orally bioavailable BET inhibitor.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/INCB-057643.html

• Concentration :

  10mM

• Purity :

  98.29

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C)(C)OC2=C(C3=CN(C)C(C4=C3C=CN4)=O)C=C(S(=O)(C)=O)C=C2N1C

• Molecular Formula :

  C20H21N3O5S

• Molecular Weight :

  415.46

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5071.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1820889-23-3]