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Entacapone (sodium salt)

CAT: 0804-HY-14280ASize: 1 EachDry Ice: NoHazardous: No
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Description
Entacapone sodium salt is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone sodium salt inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM) . Entacapone sodium salt can be used for the research of Parkinson's disease[1]. Entacapone sodium salt serves as as a inhibit of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].
CAS Number
1047659-02-8
UNSPSC
12352005
Hazard Statement
H301
Target
COMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/entacapone-sodium-salt.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C([O-])C(O)=C1.[Na+]
Molecular Formula
C14H14N3NaO5
Molecular Weight
327.27
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]E Nissinen, et al. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor Entacapone sodium salt . Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346 (3) :262-6.|[2]Shiming Peng, et al. Identification of Entacapone sodium salt as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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A21888-5Entacapone sodium salt 5mg
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A21888-10Entacapone sodium salt 10mg
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