Products for Research Use Only
RegisterLogin

Entacapone (Standard)

CAT: 0804-HY-14280R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14280R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Entacapone (Standard) is the analytical standard of Entacapone. This product is intended for research and analytical applications. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM) . Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].
CAS Number
130929-57-6
UNSPSC
12352005
Target
COMT; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/entacapone-standard.html
Purity
99.24
Smiles
O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
Molecular Formula
C14H15N3O5
Molecular Weight
305.29
References & Citations
[1]E Nissinen, et al. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346 (3) :262-6.|[2]Shiming Peng, et al. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Related Products

CatalogName
HY-14280-01Entacapone
HY-125350Entacapone acid
HY-139089-01(Z) -Entacapone
HY-14280S-01Entacapone-d10
HY-14280AEntacapone (sodium salt)
HY-14280S2(E)-Entacapone-d10
HY-139089S(Z) -Entacapone-d10
HY-W704878(Z) -Entacapone-d10-1
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)

Alternative Products

CatalogName
A4168-100Entacapone

Popular Products