CHPG (sodium salt)

• Description :

  CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].

• UNSPSC :

  12352005

• Target :

  Akt; ERK; mGluR; NF-κB

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/chpg-sodium-salt.html

• Concentration :

  10mM

• Purity :

  99.25

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C(O[Na])C(N)C1=CC(O)=CC=C1Cl

• Molecular Formula :

  C8H7ClNNaO3

• Molecular Weight :

  223.59

• References & Citations :

  2

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERK; mGluR5; NF-κB

• Citation 01 :

  Immunobiology. 2025 Jun 28;230 (4) :153095.|SSRN. 2025 Aug 27.|IBRO Neurosci Rep. 2025 May 26:18:823-829.|World J Gastroenterol. 2025 Feb 21;31 (7) :98852.

• CAS Number :

  [1303993-73-8]