CHPG (sodium salt)

• Description:

  CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].

• UNSPSC:

  12352005

• Target:

  Akt; ERK; mGluR; NF-κB

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/chpg-sodium-salt.html

• Concentration:

  10mM

• Purity:

  99.25

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C (O[Na]) C (N) C1=CC (O) =CC=C1Cl

• Molecular Formula:

  C8H7ClNNaO3

• Molecular Weight:

  223.59

• References & Citations:

  2

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ERK; mGluR5; NF-κB

• Citation 01:

  Immunobiology. 2025 Jun 28;230 (4) :153095.|SSRN. 2025 Aug 27.|IBRO Neurosci Rep. 2025 May 26:18:823-829.|World J Gastroenterol. 2025 Feb 21;31 (7) :98852.

• CAS Number:

  1303993-73-8