AMG 837

• Description :

  AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Free Fatty Acid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/AMG-837.html

• Purity :

  98.5900

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(C[C@H](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O

• Molecular Formula :

  C26H21F3O3

• Molecular Weight :

  438.44

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22 (2) :1267-70.|[2]Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6 (11) :e27270.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Biomed Pharmacother. 2023 May:161:114509.|Biochem Biophys Res Commun. 2025 Apr 9:757:151624.

• CAS Number :

  [865231-46-5]