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AMG 837

CAT: 0804-HY-13967-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13967-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[865231-46-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/AMG-837.html
Purity
98.5900
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C[C@H](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O
Molecular Formula
C26H21F3O3
Molecular Weight
438.44
Precautions
H315, H319, H335
References & Citations
[1]Houze JB, et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22 (2) :1267-70.|[2]Lin DC, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6 (11) :e27270.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Biomed Pharmacother. 2023 May:161:114509.|Biochem Biophys Res Commun. 2025 Apr 9:757:151624.

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