AC710 (Mesylate)

• Description:

  AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

• UNSPSC:

  12352005

• Target:

  PDGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ac710-mesylate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1=NC=C (OC2CC (C) (C) N (CC) C (C) (C) C2) C=C1) NC3=CC=C (NC (NC4=NOC (C (C) (C) C) =C4) =O) C=C3.CS (=O) (O) =O

• Molecular Formula:

  C32H46N6O7S

• Molecular Weight:

  658.81

• References & Citations:

  [1]Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3 (12) :997-1002.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDGFRα; PDGFRβ

• CAS Number:

  1351522-05-8