AC710 (Mesylate)

CAT: 0804-HY-13493ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13493ASize:1 Each
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Description
AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
CAS Number
[1351522-05-8]
UNSPSC
12352005
Target
PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac710-mesylate.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(OC2CC(C)(C)N(CC)C(C)(C)C2)C=C1)NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3.CS(=O)(O)=O
Molecular Formula
C32H46N6O7S
Molecular Weight
658.81
References & Citations
[1]Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3 (12) :997-1002.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRα; PDGFRβ

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