AC710

CAT: 0804-HY-13493-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13493-01Size:5 mg
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Description
AC710 is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
CAS Number
[1351522-04-7]
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
C-Kit; FLT3; PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AC710.html
Purity
99.13
Solubility
DMSO : 14 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=NC=C(OC2CC(C)(C)N(CC)C(C)(C)C2)C=C1)NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3
Molecular Formula
C31H42N6O4
Molecular Weight
562.70
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3 (12) :997-1002.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRα; PDGFRβ

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