NVS-CRF38
CAT:
804-HY-12339
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NVS-CRF38
- CAS Number: 1207258-55-6
- UNSPSC Description: NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. IC50 value: Target: CRF1 antagonist
- Target Antigen: CRFR
- Type: Reference compound
- Related Pathways: GPCR/G Protein
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Endocrinology
- Assay Protocol: https://www.medchemexpress.com/nvs-crf38.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC(C)=C(C2=C(C)OC3=C(N4N=C(C)N=C4C)C(C)=NN32)C=C1
- Molecular Weight: 351.40
- References & Citations: [1]Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3.|[2]Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported