NVS-CRF38

• Description:

  NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. IC50 value: Target: CRF1 antagonist

• UNSPSC:

  12352005

• Target:

  CRFR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/nvs-crf38.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC (C) =C (C2=C (C) OC3=C (N4N=C (C) N=C4C) C (C) =NN32) C=C1

• Molecular Formula:

  C19H21N5O2

• Molecular Weight:

  351.40

• References & Citations:

  [1]Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3.|[2]Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42 (7) :1117-24.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CRFR1

• CAS Number:

  1207258-55-6