NVS-STG2

• UNSPSC Description:

  NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models[1][2].

• Target Antigen:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/nvs-stg2.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=C(C=CC(C(O)=O)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C

• Molecular Weight:

  427.53

• References & Citations:

  [1]Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12.|[2]Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3030588-01-0