NVS-STG2

• Description:

  NVS-STG2 is a molecular glue that targets STING[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Molecular Glues; STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nvs-stg2.html

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=C(C=CC(C(O)=O)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C

• Molecular Formula:

  C25H33NO5

• Molecular Weight:

  427.53

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12.|[2]Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3030588-01-0]