CSF1R-IN-22

CSF1R-IN-22

• CAS Number: 2760585-35-9
• UNSPSC Description: CSF1R-IN-22 (Compound C19) is an orally effective CSF-1R selective inhibitor (IC50+ T cell infiltration. CSF1R-IN-22 boosts anti-tumor immune responses of anti-PD-1, and induces apoptosis in tumor cells. CSF1R-IN-22 can effectively reprogram M2-like TAMs (tumor-associated macrophages) to the M1 phenotype and reshape the TME by inducing the recruitment of CD8+ T cells into tumors and reducing the infiltration of immunosuppressive Tregs and MDSCs[1].
• Target Antigen: Apoptosis; c-Fms
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/csf1r-in-22.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)(C1=CC(NC(NC2=CC(NC/3=O)=C(C=C2)C3=C\C4=CN=CN4)=O)=NO1)C
• Molecular Weight: 392.41
• References & Citations: [1]Lv Q, et al. Discovery of a Novel CSF-1R Inhibitor with Highly Improved Pharmacokinetic Profiles and Superior Efficacy in Colorectal Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6854-6879.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported