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SNAP 94847

CAT: 0804-HY-107625Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107625Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3].
CAS Number
487051-12-7
UNSPSC
12352005
Hazard Statement
H410
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/snap-94847.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(NC(C(C)C)=O)C=C1C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2
Molecular Formula
C29H32F2N2O2
Molecular Weight
478.57
Precautions
P273-P391-P501
References & Citations
[1]David DJ, et al. Efficacy of the MCHR1 antagonist N-[3- (1-{[4- (3,4-difluorophenoxy) phenyl]methyl} (4-piperidyl) ) -4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321 (1) :237-48. Epub 2007 Jan 19.|[2]Nair SG, et al. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.Psychopharmacology (Berl) . 2009 Jul;205 (1) :129-40.|[3]Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.J Med Chem. 2007 Aug 9;50 (16) :3883-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide
CAS Number487051-12-7
PubChem CID16756754
IUPAC NameN-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]piperidin-4-yl]-4-methylphenyl]-2-methylpropanamide
Molecular FormulaC29H32F2N2O2
Molecular Weight478.6
XLogP6.3
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity661
SMILES
CC1=C(C=C(C=C1)NC(=O)C(C)C)C2CCN(CC2)CC3=CC=C(C=C3)OC4=CC(=C(C=C4)F)F
InChI
InChI=1S/C29H32F2N2O2/c1-19(2)29(34)32-23-7-4-20(3)26(16-23)22-12-14-33(15-13-22)18-21-5-8-24(9-6-21)35-25-10-11-27(30)28(31)17-25/h4-11,16-17,19,22H,12-15,18H2,1-3H3,(H,32,34)
InChIKey
VMLZFUVIKCGATC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide
CAS: 487051-12-7
CID: 16756754
Formula: C29H32F2N2O2
MW: 478.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.6
XLogP36.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass478.24318459
Monoisotopic Mass478.24318459
Topological Polar Surface Area41.6 Ų
Heavy Atom Count35
Formal Charge0
Complexity661
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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