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IPMK Colorimetric Cell-Based ELISA

CAT: 0519-EKC1876Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1876Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IPMK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IPMK protein expression profile in cells. The kit can be used for measuring the relative amounts of IPMK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IPMK.
Synonyms
Inositol polyphosphate multikinase;2.7.1.151; Inositol 1,3,4,6-tetrakisphosphate 5-kinase; IPMK; IMPK
Gene Name
IPMK
UniProt
Q8NFU5
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins (1,4,5) P3) and inositol 1,3,4,6-tetrakisphosphate (Ins (1,3,4,6) P4) (PubMed:12027805, PubMed:12223481) . Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610) .
Molecular Weight
47222 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Inositol polyphosphate multikinase
Subcellular Location
Nucleus.

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