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RBM5 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1744Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1744Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The RBM5 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor RBM5 protein expression profile in cells. The kit can be used for measuring the relative amounts of RBM5 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on RBM5.
Synonyms
RNA-binding protein 5; Protein G15; Putative tumor suppressor LUCA15; RNA-binding motif protein 5; Renal carcinoma antigen NY-REN-9; RBM5; H37, LUCA15
Gene Name
RBM5
UniProt
P52756
Reactivity
Human, Mouse
Tissue Specificity
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Molecular Weight
92154 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
RNA-binding protein 5
Subcellular Location
Nucleus.

UniProtKB · P52756

RNA-binding protein 5

RBM5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52756
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RBM5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RA45, B4DM16, B4DMF9, B4DZ63, Q93021, Q9BU14, Q9HDA6, Q9UKY8, Q9UL24
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosismRNA processingmRNA splicing

Ligand

Metal-bindingZinc

Cellular component

NucleusSpliceosome

PTM

Phosphoprotein

Domain

RepeatZinc-finger

Molecular function

RNA-binding

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