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M3K13 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1631Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1631Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The M3K13 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor M3K13 protein expression profile in cells. The kit can be used for measuring the relative amounts of M3K13 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on M3K13.
Synonyms
Mitogen-activated protein kinase kinase kinase 13;2.7.11.25; Leucine zipper-bearing kinase; Mixed lineage kinase; MLK; MAP3K13 ; LZK
Gene Name
MAP3K13 LZK
UniProt
O43283
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Molecular Weight
108296 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Mitogen-activated protein kinase kinase kinase 13
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.

UniProtKB · O43283

Mitogen-activated protein kinase kinase kinase 13

M3K13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43283
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, Q05BY6, Q15450, Q2NKN3
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

CytoplasmMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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