BMX Colorimetric Cell-Based ELISA

• Description:

  The BMX Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BMX protein expression profile in cells. The kit can be used for measuring the relative amounts of BMX in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BMX.

• Synonyms:

  Cytoplasmic tyrosine-protein kinase BMX;2.7.10.2; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38; BMX

• Gene Name:

  BMX

• UniProt:

  P51813

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

• Molecular Weight:

  78011 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Cytoplasmic tyrosine-protein kinase BMX

• Subcellular Location:

  Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1.